Aromatase inhibitors come of age

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Aromatase inhibitors versus antioestrogens

Endocrine therapies act by either blocking or downregulating the oestrogen receptor or by reducing oestrogen concentrations around and within the cancer cell. In postmenopausal women, oestrogen suppression is achieved by inhibition of the enzyme aromatase by aromatase inhibitors (AIs). Modern AIs (anastrozole, letrozole and exemestane) are more potent than earlier ones and suppress oestradiol l...

متن کامل

Molecular Docking of Aromatase Inhibitors

Aromatase is an enzyme that plays a critical role in the development of estrogen receptor positive breast cancer. As aromatase catalyzes the aromatization of androstenedione to estrone, a naturally occurring estrogen, it is a promising drug target for therapeutic management. The undesirable effects found in aromatase inhibitors (AIs) that are in clinical use necessitate the discovery of novel A...

متن کامل

Neocentromeres Come of Age

Sixteen years ago, the discovery of a newly formed, ectopic centromere in a human [1,2] was a turning point for centromere research. Whereas previously centromeres had been thought of as immovable and unchanging, embedded in vast tracts of tandemly repeated DNA, this new centromere—or neocentromere—lacked any characteristic centromeric DNA sequences and had formed in a gene-rich area of the gen...

متن کامل

Chaperones come of age.

Chaperone function plays a key role in repairing proteotoxic damage, in the maintenance of cell architecture, and in cell survival. Here, we summarize our current knowledge about changes in chaperone expression and function in the aging process, as well as their involvement in longevity and cellular senescence.

متن کامل

Ontologies Come of Age

Ontologies have moved beyond the domains of library science, philosophy, and knowledge representation. They are now the concerns of marketing departments, CEOs, and mainstream business. Research analyst companies such as Forrester Research report on the critical roles of ontologies in support of browsing and search for e-commerce and in support of interoperability for facilitation of knowledge ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Annals of Oncology

سال: 1997

ISSN: 0923-7534

DOI: 10.1023/a:1008282315089